Victor Caratini hit a two-run walk off bomb to propel the Astros over the Guardians in extra innings, 10-9.
Joey Loperfido had a two RBI single in his Major League debut.
Jon Singleton and Alex Bregman both hit three run homers while Jose Altuve, Kyle Tucker and Jeremy Pena all had two hit nights in the win.
Game two of the series is tonight at Minute Maid Park. 7:10pm is the first pitch with coverage starting at 6pm on SportsTalk790.